{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:49:32Z","timestamp":1760953772520},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1964,6,1]]},"abstract":"<jats:p>Large doses of 7,12-dimethylbenz[a]anthracene (7,12-DMBA) caused the death of rats within 1 day. A small amount of any of 5 polynuclear aromatic hydrocarbons or of an aromatic amine given before the highly toxic dose of 7,12-DMBA resulted in survival for more than 2 months and the specific atrophy of testis which follows 7,12-DMBA was largely prevented. Among the protective aromatics is 7,12-DMBA itself; a small dose of 7,12-DMBA given in advance induced protection of life against an otherwise lethal dose of 7,12-DMBA but only in a proportion of the animals, and testis was not protected from injury. The highly efficient inducers of protection were condensed aromatics composed of 4 or 5 rings.<\/jats:p>\n               <jats:p>Protection of life against toxicity of big doses of 7,12-DMBA by pretreatment with small doses of aromatics required time (ca. 5 to 8 hours) for its induction. Ethionine given a few minutes after a highly efficient inducer of protection, 3-methylcholanthrene (3-MC), abolished induction of protection; ethionine given 8 hours after 3-MC exerted no influence on its protective effect.<\/jats:p>\n               <jats:p>A lethal dose of 7,12-DMBA resulted in a considerable reduction in incorporation of tritium in DNA from tritiated thymidine while at the same time synthesis of menadione reductase was induced in liver. A small dose of 3-MC given prior to 7,12-DMBA was advantageous in partially protecting DNA synthesis.<\/jats:p>","DOI":"10.1084\/jem.119.6.943","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"943-954","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["AROMATIC-INDUCED PREVENTION OF FATAL TOXICITY OF 7,12-DIMETHYLBENZ[<i>a<\/i>]ANTHRACENE"],"prefix":"10.1084","volume":"119","author":[{"given":"Charles","family":"Huggins","sequence":"first","affiliation":[{"name":"From the Ben May Laboratory for Cancer Research, The University of Chicago, Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Ford","sequence":"additional","affiliation":[{"name":"From the Ben May Laboratory for Cancer Research, The University of Chicago, Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Fukunishi","sequence":"additional","affiliation":[{"name":"From the Ben May Laboratory for Cancer Research, The University of Chicago, Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. V.","family":"Jensen","sequence":"additional","affiliation":[{"name":"From the Ben May Laboratory for Cancer Research, The University of Chicago, Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1964,6,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/119\/6\/943\/1650195\/943.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/119\/6\/943\/1650195\/943.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T19:37:03Z","timestamp":1690227423000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/119\/6\/943\/21597\/AROMATIC-INDUCED-PREVENTION-OF-FATAL-TOXICITY-OF-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1964,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1964,6,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.119.6.943","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1964,6,1]]}}}