{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:49:50Z","timestamp":1759693790599},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1965,10,1]]},"abstract":"<jats:p>Polyarthritis and cardiac lesions have been observed in the adult rat with homologous disease. Changes in the lymphoid tissue and kidney have also been noted.<\/jats:p>\n               <jats:p>A migratory polyarthritis occurred in over half of the affected animals, and cardiac involvement of varying intensity was present in all. Histologically, the arthritis was characterized by a mononuclear synovial inflammatory reaction. In the heart, the valves and myocardium demonstrated a similar type of response. Cultures of involved joints and hearts for pyogens and pleuropneumonia-like organisms were negative.<\/jats:p>\n               <jats:p>The lymphoid tissues showed progressive changes in three stages: (a) disappearance of follicles; (b) increase in plasma-like cells and histiocytes; and (c) fibrosis. The second stage tended to coincide with the development of the polyarthritis. The kidney showed mild interstitial mononuclear infiltration.<\/jats:p>\n               <jats:p>The pathologic changes described appear to be a consequence of reaction between foreign immunologically competent cells and host antigens, but the possibility that these lesions represent a response to antigens derived from unknown infectious agents is, however, not ruled out.<\/jats:p>","DOI":"10.1084\/jem.122.4.681","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"681-692","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["HOMOLOGOUS DISEASE IN THE ADULT RAT, A MODEL FOR AUTOIMMUNE DISEASE"],"prefix":"10.1084","volume":"122","author":[{"given":"Peter","family":"Stastny","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine, Rheumatic Diseases Unit, and the Department of Pathology, The University of Texas Southwestern Medical School, Dallas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vernie A.","family":"Stembridge","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Rheumatic Diseases Unit, and the Department of Pathology, The University of Texas Southwestern Medical School, Dallas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Vischer","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Rheumatic Diseases Unit, and the Department of Pathology, The University of Texas Southwestern Medical School, Dallas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Ziff","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Rheumatic Diseases Unit, and the Department of Pathology, The University of Texas Southwestern Medical School, Dallas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1965,10,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/122\/4\/681\/1650959\/681.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/122\/4\/681\/1650959\/681.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T19:48:56Z","timestamp":1690228136000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/122\/4\/681\/3883\/HOMOLOGOUS-DISEASE-IN-THE-ADULT-RAT-A-MODEL-FOR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1965,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.122.4.681","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1965,10,1]]}}}