{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:58:52Z","timestamp":1759694332748},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1966,12,1]]},"abstract":"<jats:p>A filtrable agent separable from transplantable malignant lymphomas of NZB\/Bl mice was capable, upon inoculation into preweanling NZB\/Bl mice, of inducing lymphoid cell hyperplasia, hypergammaglobulinemia, proteinuria, hypoalbuminemia, and pathological changes (focal membranous glomerulonephritis) of kidneys\u2014renal functional and structural changes qualitatively similar to those of spontaneous occurrence in older NZB\/Bl mice.<\/jats:p>\n               <jats:p>Viruslike particles with close resemblance to the typical \"C\" type murine oncogenic virus particles were identified by means of electron microscopy in NZB\/Bl mouse tissues and cells, including malignant lymphoma cells, benign lymphoid cells of thymus and spleen, epithelial cells of renal tubules, and extracellular sites.<\/jats:p>\n               <jats:p>The relevance of these observations, the first of their kind dealing with NZB\/Bl mice, is discussed in relation to the several immunopathological disorders which characterize this strain of mice.<\/jats:p>","DOI":"10.1084\/jem.124.6.1031","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T23:23:31Z","timestamp":1088033011000},"page":"1031-1038","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":108,"title":["IMMUNOPATHOLOGY OF NZB\/BL MICE"],"prefix":"10.1084","volume":"124","author":[{"given":"Robert C.","family":"Mellors","sequence":"first","affiliation":[{"name":"From The Hospital for Special Surgery, Affiliated with the New York Hospital-Cornell University Medical College, and the Departments of Pathology and Anatomy, Cornell University Medical College, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen Ya","family":"Huang","sequence":"additional","affiliation":[{"name":"From The Hospital for Special Surgery, Affiliated with the New York Hospital-Cornell University Medical College, and the Departments of Pathology and Anatomy, Cornell University Medical College, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1966,12,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/124\/6\/1031\/1651706\/1031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/124\/6\/1031\/1651706\/1031.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T20:00:17Z","timestamp":1690228817000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/124\/6\/1031\/5454\/IMMUNOPATHOLOGY-OF-NZB-BL-MICE-V-VIRUSLIKE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1966,12,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.124.6.1031","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1966,12,1]]}}}