{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:27:52Z","timestamp":1777418872671,"version":"3.51.4"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1968,12,1]]},"abstract":"<jats:p>The immunochemical specificity of antigen-induced inhibition of peritoneal exudate cell migration was studied in animals sensitized to chemically defined \u03b1,DNP(Lys)18 peptides. It was shown that sensitized peritoneal exudate cells could discriminate between various DNP-oligolysines. Only immunogenic members of the homologous series of \u03b1,DNP-L-lysines equal to or larger in size than the heptamer inhibited the migration of specifically sensitized peritoneal exudate cells. In contrast, nonimmunogenic \u03b1,DNP-L-lysines, a D-lysine containing stereoisomer of \u03b1,DNP L(Lys)9 (\u03b1,DNP-L4DL4) and (Lys)9\u03f5, DNP were not inhibitory to the migration of peritoneal exudate cells derived from animals immunized to \u03b1,DNP(Lys)18.<\/jats:p>\n               <jats:p>The exquisite specificity of the in vitro reaction of sensitized cells with antigen contrasts with the previously observed in vivo or in vitro specificity of anti-\u03b1,-DNP(Lys)n antibody, but parallels the specificity of the in vivo delayed or anamnestic response. These results suggest the presence of a still undefined but highly specific binding site, which functions as the cellular receptor for antigen on the sensitized lymphoid cell or on some \"processing\" cell.<\/jats:p>","DOI":"10.1084\/jem.128.6.1451","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T23:23:31Z","timestamp":1088033011000},"page":"1451-1459","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["IMMUNOCHEMICAL STUDIES ON THE SPECIFICITY OF CELLULAR HYPERSENSITIVITY"],"prefix":"10.1084","volume":"128","author":[{"given":"John R.","family":"David","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Harvard Medical School, Robert B. Brigham and Beth Israel Hospitals, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart F.","family":"Schlossman","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Harvard Medical School, Robert B. Brigham and Beth Israel Hospitals, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1968,12,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/128\/6\/1451\/1652960\/1451.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/128\/6\/1451\/1652960\/1451.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T20:27:01Z","timestamp":1690230421000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/128\/6\/1451\/31330\/IMMUNOCHEMICAL-STUDIES-ON-THE-SPECIFICITY-OF"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1968,12,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.128.6.1451","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1968,12,1]]}}}