{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:38:00Z","timestamp":1761154680716},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1970,8,1]]},"abstract":"<jats:p>The present study defines the early response of normal rabbits to the intravenous injection of a single, sublethal dose of endotoxin. Within the first few hours following endotoxin there occurs in the circulating plasma of recipients a decrease in ionized calcium, a threefold increase in the heat-stable, organo-phosphate-resistant esterase level, and a striking increase in the endotoxin-detoxifying capacity. These results are fully consistent with the thesis that circulating plasma represents a principal site of detoxification and that plasma esterases of the nonspecific, carboxylic type are of major concern in defense against circulating endotoxins.<\/jats:p>","DOI":"10.1084\/jem.132.2.300","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T23:23:31Z","timestamp":1088033011000},"page":"300-316","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["HOST DEFENSE AGAINST BACTERIAL ENDOTOXEMIA: MECHANISM IN NORMAL ANIMALS"],"prefix":"10.1084","volume":"132","author":[{"given":"Robert C.","family":"Skarnes","sequence":"first","affiliation":[{"name":"From The Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1970,8,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/132\/2\/300\/1653633\/300.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/132\/2\/300\/1653633\/300.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T20:37:53Z","timestamp":1690231073000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/132\/2\/300\/5924\/HOST-DEFENSE-AGAINST-BACTERIAL-ENDOTOXEMIA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1970,8,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.132.2.300","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1970,8,1]]}}}