{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:46:48Z","timestamp":1761058008711},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1972,10,1]]},"abstract":"<jats:p>All 110 rabbits immunized with Group A, A-variant, and C streptococcal vaccines produced 19S anti-IgG in addition to antibodies to the streptococcal carbohydrates. 19S anti-IgG was detected by hemagglutination of rabbit red blood cells coated with rabbit anti-blood group F antibody. Antisera of 88 of these animals were also tested for 7S anti-IgG with a coprecipitation assay. This assay is based on the coprecipitation of 7S anti-IgG with complexes of streptococcal carbohydrate and anti-carbohydrate antibody. 50 of the 88 anti-Group C streptococcal antisera contained 7S anti-IgGs. In eight antisera the concentration was greater than 5 mg\/ml.<\/jats:p>\n               <jats:p>The data suggest a genetic influence on the occurrence of 7S anti-IgG. The eight rabbits which produced more than 5 mg\/ml of 7S anti-IgG belonged to three related families. Moreover, there were families in which almost every member produced 7S anti-IgG and other families in which only 30% of the members manufactured 7S anti-IgG.<\/jats:p>\n               <jats:p>The streptococcal vaccine was an especially efficient stimulus for the production of 19S anti-IgG, whereas the pneumococcal vaccine was much less effective in this respect. Furthermore, 7S anti-IgGs were not detected in antipneumococcal antisera, although the concentration of anti-capsular antibodies was similar to that of anti-carbohydrate antibodies in antistreptococcal antisera.<\/jats:p>","DOI":"10.1084\/jem.136.4.799","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T23:23:31Z","timestamp":1088033011000},"page":"799-815","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["OCCURRENCE OF 19S AND 7S ANTI-I<scp>G<\/scp>G<scp>S<\/scp> DURING HYPERIMMUNIZATION OF RABBITS WITH STREPTOCOCCI"],"prefix":"10.1084","volume":"136","author":[{"given":"Viktor A.","family":"Bokisch","sequence":"first","affiliation":[{"name":"From The Rockefeller University, New York 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bernstein","sequence":"additional","affiliation":[{"name":"From The Rockefeller University, New York 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Krause","sequence":"additional","affiliation":[{"name":"From The Rockefeller University, New York 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1972,10,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/136\/4\/799\/1654901\/799.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/136\/4\/799\/1654901\/799.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T20:57:27Z","timestamp":1690232247000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/136\/4\/799\/6293\/OCCURRENCE-OF-19S-AND-7S-ANTI-IGGS-DURING"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1972,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.136.4.799","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1972,10,1]]}}}