{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:04:49Z","timestamp":1762067089509},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1973,7,1]]},"abstract":"<jats:p>Conventional Swiss mice were treated from birth with intraperitoneal injections of anti-immunoglobulins in an attempt to create an experimental dysgammaglobulinemia. Mice treated with anti-\u03b3M were immunologically suppressed in all immunoglobulin classes as determined by serum antibody titers, splenic plaque-forming cells, serum immunoglobulin levels, and immunofluorescent analysis of plasma cells in lymphoid tissues. Treatment immediately after birth with high concentrations of anti-\u03b3M leads to a developmental arrest characterized by severe immunosuppression, failure to gain weight, and premature death. The pathogenesis of anti-\u03b3M runting syndrome is unknown. Animals similarly treated with anti-\u03b3G, anti-\u03b3A, or control normal goat or rabbit \u03b3-globulins developed normally. The frequency of occurrence and severity of anti-\u03b3M-induced runting syndrome is dependent upon the concentration of anti-\u03b3M-globulin administered.<\/jats:p>\n               <jats:p>Administration of anti-\u03b3A resulted in a selective \u03b3A deficiency that was characterized by a marked reduction in serum-\u03b3A and an absence of \u03b3A-containing cells in the spleen. However, essentially normal numbers of plasma cells were found in the gastrointestinal lamina propria of anti-\u03b3A-treated animals concomitantly with suppressed levels of \u03b3A in intestinal fluids.<\/jats:p>","DOI":"10.1084\/jem.138.1.209","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T23:23:31Z","timestamp":1088033011000},"page":"209-228","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["PRODUCTION OF A RUNTING SYNDROME AND SELECTIVE \u03b3A DEFICIENCY IN MICE BY THE ADMINISTRATION OF ANTI-HEAVY CHAIN ANTISERA"],"prefix":"10.1084","volume":"138","author":[{"given":"Robert A.","family":"Murgita","sequence":"first","affiliation":[{"name":"From the Department of Immunology, Mayo Medical School, Rochester, Minnesota 55901"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Mattioli","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, Mayo Medical School, Rochester, Minnesota 55901"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Thomas B.","family":"Tomasi","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, Mayo Medical School, Rochester, Minnesota 55901"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1973,7,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/138\/1\/209\/1655519\/209.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/138\/1\/209\/1655519\/209.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T21:07:34Z","timestamp":1690232854000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/138\/1\/209\/6418\/PRODUCTION-OF-A-RUNTING-SYNDROME-AND-SELECTIVE-A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1973,7,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.138.1.209","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1973,7,1]]}}}