{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:28:00Z","timestamp":1768285680292,"version":"3.49.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1973,10,1]]},"abstract":"<jats:p>Factor VIII coagulant activity (VIIIC) and the von Willebrand's disease antigen (Factor VIII-like antigen, vW-Ag) are biologically linked, and it has been suggested that they reside on the same molecule. However, insolubilized human isoantibody to VIIIC and rabbit antiserum containing antibodies to VIIIC and vW-Ag differentially bind and remove these entities from plasma, thus physically segregating one from the other. These findings indicate that Factor VIII coagulant activity resides on a molecule distinct from that expressing the von Willebrand's antigen.<\/jats:p>","DOI":"10.1084\/jem.138.4.1015","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T23:23:31Z","timestamp":1088033011000},"page":"1015-1020","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":73,"title":["FACTOR VIII COAGULANT ACTIVITY AND FACTOR VIII-LIKE ANTIGEN: INDEPENDENT MOLECULAR ENTITIES"],"prefix":"10.1084","volume":"138","author":[{"given":"Theodore S.","family":"Zimmerman","sequence":"first","affiliation":[{"name":"From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S.","family":"Edgington","sequence":"additional","affiliation":[{"name":"From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1973,10,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/138\/4\/1015\/1655712\/1015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/138\/4\/1015\/1655712\/1015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T21:10:24Z","timestamp":1690233024000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/138\/4\/1015\/21832\/FACTOR-VIII-COAGULANT-ACTIVITY-AND-FACTOR-VIII"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1973,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.138.4.1015","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1973,10,1]]}}}