{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:47:09Z","timestamp":1759693629168},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1973,10,1]]},"abstract":"<jats:p>Efforts to stimulate lymphocytes from measles seropositive and two patients with subacute sclerosing panencephalitis (SSPE) with either commercially available measles virus or virus isolated from a known case of SSPE failed to show any significant data using a microculture assay. Similar results were obtained using lymphocytes from two patients with active cytomegalovirus (CMV) infections and CMV seropositive individuals using CMV suspensions.<\/jats:p>\n               <jats:p>On the other hand, lymphocytes from the patients with subacute sclerosing panencephalitis exhibited in vitro blastogenesis in culture with SSPE virus-infected HeLa cells. Similarly, lymphocytes from the CMV-infected patients demonstrated blastogenesis when cocultivated with CMV-infected WI-38 cells. This affords a new method for determining the cell-mediated immune capacity of patients with \"slow\" virus diseases.<\/jats:p>","DOI":"10.1084\/jem.138.4.839","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T23:23:31Z","timestamp":1088033011000},"page":"839-846","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS"],"prefix":"10.1084","volume":"138","author":[{"given":"G. B.","family":"Thurman","sequence":"first","affiliation":[{"name":"From the Experimental Immunology Division, Clinical Medical Sciences Department, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"From the Experimental Immunology Division, Clinical Medical Sciences Department, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Strong","sequence":"additional","affiliation":[{"name":"From the Experimental Immunology Division, Clinical Medical Sciences Department, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Knudsen","sequence":"additional","affiliation":[{"name":"From the Experimental Immunology Division, Clinical Medical Sciences Department, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. R.","family":"Grace","sequence":"additional","affiliation":[{"name":"From the Experimental Immunology Division, Clinical Medical Sciences Department, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. W.","family":"Sell","sequence":"additional","affiliation":[{"name":"From the Experimental Immunology Division, Clinical Medical Sciences Department, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1973,10,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/138\/4\/839\/1655752\/839.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/138\/4\/839\/1655752\/839.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T21:11:03Z","timestamp":1690233063000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/138\/4\/839\/6457\/LYMPHOCYTE-ACTIVATION-IN-SUBACUTE-SCLEROSING"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1973,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.138.4.839","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1973,10,1]]}}}