{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:01:50Z","timestamp":1782982910984,"version":"3.54.5"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,3,1]]},"abstract":"<jats:p>The data presented in this paper support the hypothesis that unresponsiveness to autologous thyroglobulin (Tg) exists in the T cells and responsiveness exists in the B cells. Such a conclusion is based on the results of antigen-binding studies where few, if any, thymocytes recognized syngeneic Tg. Comparable numbers of antigen-binding lymphocytes for syngeneic Tg were found in the spleens of normal intact mice and of nude mice. The latter fact suggested that B cells exist which recognize self-constituents. From antigen-suicide experiments, a clearer picture of the susceptibility of B cells to iodinated self-antigen and of the obligatory role of antibody in the induction of lesions was developed. Only bone marrow cells (B cells) were affected by [125I]syngeneic Tg, in which case the incidence of lesions was diminished. From adoptive transfer experiments, the results demonstrate that unresponsiveness may be terminated by immunization with a mixture of heterologous (cross-reacting) Tg's. In this situation T cells are required since a B-cell reconstituted host failed to make antibody (plaque-forming cells) and to develop lesions. T cells in this form of an unresponsive state may recognize determinants on the heterologous Tg unrelated to autologous Tg and as such stimulate the normal complement of B cells to produce antibody that both reacts with autologous and heterologous Tg.<\/jats:p>","DOI":"10.1084\/jem.139.3.643","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T23:23:31Z","timestamp":1088033011000},"page":"643-660","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["ROLES OF T AND B LYMPHOCYTES IN THE TERMINATION OF UNRESPONSIVENESS TO AUTOLOGOUS THYROGLOBULIN IN MICE"],"prefix":"10.1084","volume":"139","author":[{"given":"James A.","family":"Clagett","sequence":"first","affiliation":[{"name":"From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William O.","family":"Weigle","sequence":"additional","affiliation":[{"name":"From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1974,3,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/139\/3\/643\/1655954\/643.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/139\/3\/643\/1655954\/643.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T21:15:24Z","timestamp":1690233324000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/139\/3\/643\/6523\/ROLES-OF-T-AND-B-LYMPHOCYTES-IN-THE-TERMINATION-OF"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1974,3,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.139.3.643","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1974,3,1]]}}}