{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T15:07:33Z","timestamp":1696691253091},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,3,1]]},"abstract":"<jats:p>Spleen cells from BALB\/c and C57BL\/6 mice were tested for their reactivity against reciprocal hybrid tissues ((BALB\/c x C57BL\/6) F1 and (C57BL\/6 x BALB\/c) F1) in three assay systems: the mixed lymphocyte reaction (MLR); the Simonsen spleen-weight graft-vs.-host (GVH) assay; and a GVH mortality assay. It was shown that both F1's serve as equally effective stimulators of parental cells in the MLR. In the spleen-weight assay, BALB\/c and C57BL\/6 cells were equally active in a given host, but greater splenomegaly was observed in (BALB\/c x C57BL\/6) F1 hosts regardless of the donor strain. By contrast, BALB\/c cells were much less lethal than C57BL\/6 cells in (BALB\/c x C57BL\/6) F1 hosts than in (C57BL\/6 x BALB\/c) F1 hosts, and to a lesser degree C57BL\/6 cells were less lethal than BALB\/c cells in (C57BL\/6 x BALB\/c) F1 hosts. The possibility that modifying substances may differentially alter reactivity of parental lymphocytes and that considerations other than genotype determine the outcome of a GVH reaction are discussed in detail.<\/jats:p>","DOI":"10.1084\/jem.139.3.721","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T23:23:31Z","timestamp":1088033011000},"page":"721-731","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["GRAFT-VS.-HOST REACTIONS IN RECIPROCAL HYBRID MICE"],"prefix":"10.1084","volume":"139","author":[{"suffix":"III","given":"Herbert C.","family":"Morse","sequence":"first","affiliation":[{"name":"From the Laboratory of Microbial Immunity, and the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Harrison","sequence":"additional","affiliation":[{"name":"From the Laboratory of Microbial Immunity, and the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Asofsky","sequence":"additional","affiliation":[{"name":"From the Laboratory of Microbial Immunity, and the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1974,3,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/139\/3\/721\/1656033\/721.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/139\/3\/721\/1656033\/721.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T21:17:21Z","timestamp":1690233441000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/139\/3\/721\/6541\/GRAFT-VS-HOST-REACTIONS-IN-RECIPROCAL-HYBRID-MICE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1974,3,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.139.3.721","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1974,3,1]]}}}