{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:27:03Z","timestamp":1772803623509,"version":"3.50.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,8,1]]},"abstract":"<jats:p>The genetic control of the antibody response to a synthetic polypeptide antigen designated poly-L(Tyr, Glu)-poly-D,L-Ala--poly-L-Lys [(T, G)-A--L] has been studied in congenic high responder C3H.SW (H-2b) and low responder C3H\/HeJ (H-2k) strains of mice. This response is controlled by the Ir-1 gene and is H-2 linked. The method employed was to study the ability of specifically primed or \"educated\" T cells of each strain to produce cooperative factors for (T, G)-A--L in vitro. Such factors have been shown to be capable of replacing the requirement for T cells in the thymus-dependent antibody response to (T, G)-A--L in vivo. The T-cell factors produced were tested for their ability to cooperate with B cells of either high or low responder origin by transfer together with bone marrow cells and (T, G)-A--L into heavily irradiated, syngeneic (for bone marrow donor) recipients. Direct anti-(T, G)-A--L plaque-forming cells were measured later in the spleens of the recipients. The results showed that (a) educated T cells of both high and low responder origin produced active cooperative factors to (T, G)-A--L, and no differences between the strains in respect to production of T-cell factors could be demonstrated; and (b) such factors, whether of high or low responder origin, cooperated efficiently with B cells of high responder origin only, and hardly at all with B cells of low responder origin. The conclusion was drawn that the cellular difference between the two strains lies in the responsiveness of their B cells to specific signals or stimuli received from T cells. As far as could be discerned by the methods used, no T-cell defect existed in low responder mice and the expression of the controlling Ir-1 gene was solely at the level of the B cells in this case.<\/jats:p>","DOI":"10.1084\/jem.140.2.301","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T23:23:31Z","timestamp":1088033011000},"page":"301-312","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":101,"title":["ANTIGEN-SPECIFIC THYMUS CELL FACTORS IN THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO POLY-(TYROSYL, GLUTAMYL)-POLY-<scp>D, L<\/scp>-ALANYL--POLY-LYSYL"],"prefix":"10.1084","volume":"140","author":[{"given":"M. J.","family":"Taussig","sequence":"first","affiliation":[{"name":"From the Immunology Division, Department of Pathology, University of Cambridge, Cambridge, England, and the Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edna","family":"Mozes","sequence":"additional","affiliation":[{"name":"From the Immunology Division, Department of Pathology, University of Cambridge, Cambridge, England, and the Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit","family":"Isac","sequence":"additional","affiliation":[{"name":"From the Immunology Division, Department of Pathology, University of Cambridge, Cambridge, England, and the Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1974,8,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/140\/2\/301\/1895155\/301.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/140\/2\/301\/1895155\/301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T23:01:43Z","timestamp":1690671703000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/140\/2\/301\/6597\/ANTIGEN-SPECIFIC-THYMUS-CELL-FACTORS-IN-THE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1974,8,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.140.2.301","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1974,8,1]]}}}