{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:58:18Z","timestamp":1778731098899,"version":"3.51.4"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,4,1]]},"abstract":"<jats:p>Transplanted lymphomas, most of thymic origin, induced in BALB\/c mice with 1-ethyl-1-nitrosourea (ENU) and transplanted spontaneously occurring lymphomas of AKR mice were examined for the expression of the T-cell antigens Ly, TL, and Thy 1 by using three serological methods. Most (11 of 13) of the Thy 1+ and\/or TL+ tumors, i.e., T-cell tumors, expressed high levels of either Ly 1 or Ly 2 antigen, but not both. Thus most thymic lymphocytic tumors expressed restricted Ly phenotypes comparable to phenotypes previously described for functional peripheral T cells. Because tumor phenotypes were stable over a number of transplant generations, they therefore appeared to be an intrinsic property of the specific tumors. The majority of the BALB\/c lymphomas were Ly 1- 2+ and also positive with anti-TL antiserum. This predominant phenotype on the BALB\/c tumors may be related to either the mode of tumor induction or to the mouse strain, but since the restricted Ly pattern was observed both in BALB\/c and AKR tumors, the phenotypic restriction itself is not a consequence of either of these factors. Tumor induction by ENU per se is not responsible for Ly or TL ,ntigen expression since several non-T-cell BALB\/ c tumors, also induced by ENU, did not express either Ly or TL antigens. Data presented here suggest that the target cell for leukemogenesis may be a partially differentiated thymus cell. The restricted expression of Ly antigens on differentiating thymus cells to either the (formula: see text), phenotype may occur before the loss of TL antigen.<\/jats:p>","DOI":"10.1084\/jem.147.4.1267","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T21:00:50Z","timestamp":1088024450000},"page":"1267-1279","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Expression of Ly 1, Ly 2, Thy 1, and TL differentiation antigens on mouse T-cell tumors."],"prefix":"10.1084","volume":"147","author":[{"given":"B J","family":"Mathieson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P S","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Asofsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1978,4,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/147\/4\/1267\/1659226\/1267.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/147\/4\/1267\/1659226\/1267.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T23:46:24Z","timestamp":1690242384000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/147\/4\/1267\/22395\/Expression-of-Ly-1-Ly-2-Thy-1-and-TL"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1978,4,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.147.4.1267","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,4,1]]}}}