{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:13:54Z","timestamp":1777436034621,"version":"3.51.4"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,1,1]]},"abstract":"<jats:p>Mice of the HRS strain, which carry the mutant gene hr, were examined for abnormalities in representation of the three T-cell sets Ly1, Ly23, and Ly123 in the spleen. The salient feature of hr\/hr mice, which are immunologically deficient, in comparison with +\/hr segregants, was a gross disproportion in numbers of cells belonging to the Ly1 and Ly123 sets, at the age of 3--3.5 mo. At this age, Ly123 cells of hr\/hr spleen outnumbered Ly1 cells by 2:1, whereas in +\/hr spleens Ly123 cells were outnumbered by approximately 1:2. Cells from pooled lymph nodes of hr\/hr mice did not show a correspondingly gross disporprotion of Ly1 and Ly123 cells. Total counts of splenic T cells, and of B cells, were not significantly different in hr\/hr and +\/hr mice.<\/jats:p>","DOI":"10.1084\/jem.149.1.228","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T21:00:50Z","timestamp":1088024450000},"page":"228-233","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Disproportion in T-cell subpopulations in immunodeficient mutant hr\/hr mice."],"prefix":"10.1084","volume":"149","author":[{"given":"A B","family":"Reske-Kunz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"Scheid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E A","family":"Boyse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1979,1,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/149\/1\/228\/1659748\/228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/149\/1\/228\/1659748\/228.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T23:51:37Z","timestamp":1690242697000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/149\/1\/228\/22462\/Disproportion-in-T-cell-subpopulations-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,1,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.149.1.228","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1,1]]}}}