{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:12:26Z","timestamp":1790730746633,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,7,1]]},"abstract":"<jats:p>NZB mice and their F1 hybrids produce excessive polyclonal IgM and autoantibodies of both IgM and IgG classes. CBA\/N mice and CBA\/N-mothered F1 males fail to make antibody to many T-independent antigens and have low levels of serum IgM; further, these mice lack a population of splenic B cells characterized by a low-to-intermediate density of surface IgM. We have studied male CBA\/N, NZB, CBA\/N X NZB, NZB X CBA\/N, and CBA\/J mice; female CBA\/N X NZB mice; and males of several control crosses of NZB and CBA\/N mice. We have found that the CBA\/N X-linked defect of T-independent immune response is completely expressed in CBA\/N X NZB mice. In marked contrast to NZB mice and to NZB mice and to NZB F1 hybrids bearing at least one normal X chromosome, the CBA\/N X NZB males failed to respond to two T-independent antigens, had small numbers of splenic IgM-producing cells, barely detectable splenic IgM production, and splenic B-cell surface-Ig patterns resembling those of CBA\/N mice. These data suggest that the NZB B-cell abnormality resulting in excessive IgM production occurs almost exclusively in that population of B cells affected by the CBA\/N X chromome-linked defect. Preliminary studies suggest that CBA\/N X chromosome retards the spontaneous development of anti-erythrocyte autoantibodies in CBA\/N X NZB males. Castration, known to accelerate autoimmune disease in certain NZB F1 males, appears to have no influence on the immune functions examined in this study.<\/jats:p>","DOI":"10.1084\/jem.150.1.31","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T21:00:50Z","timestamp":1088024450000},"page":"31-43","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":58,"title":["CBA\/N X-linked B-cell defect prevents NZB B-cell hyperactivity in F1 mice."],"prefix":"10.1084","volume":"150","author":[{"given":"J D","family":"Taurog","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M","family":"Moutsopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y J","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T M","family":"Chused","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A D","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1979,7,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/150\/1\/31\/1660151\/31.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/150\/1\/31\/1660151\/31.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T23:56:05Z","timestamp":1690242965000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/150\/1\/31\/22447\/CBA-N-X-linked-B-cell-defect-prevents-NZB-B-cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,7,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.150.1.31","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,7,1]]}}}