{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:26:44Z","timestamp":1771644404039,"version":"3.50.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,9,1]]},"abstract":"<jats:p>Immunity to infection of mice with the facultative, intracellular pathogen Listeria monocytogenes was employed as a model system to investigate the immunological basis for the age-associated decline in anti-microbial immunity. In response to a sublethal immunizing infection, aged (24-mo old or more) mice displayed a smaller increase in spleen weight, spleen cellularity, and splenic T cell content than young (3- to 4-mo-old) mice. Aged mice also generated a smaller number of anti-Listeria protective T cells at the time of a peak response, in that their spleen cells were 1,000-fold less protective than equivalent numbers of spleen cells from the young donors, even when enriched T cell populations were employed. These results suggest that the impaired ability of aged mice to produce protective T cells is mainly responsible for decreased resistance of these mice to infection with Listeria.<\/jats:p>","DOI":"10.1084\/jem.154.3.821","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T21:00:50Z","timestamp":1088024450000},"page":"821-831","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Aging and antimicrobial immunity. Impaired production of mediator T cells as a basis for the decreased resistance of senescent mice to listeriosis."],"prefix":"10.1084","volume":"154","author":[{"given":"P J","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1981,9,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/154\/3\/821\/1662346\/821.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/154\/3\/821\/1662346\/821.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:22:20Z","timestamp":1690244540000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/154\/3\/821\/49252\/Aging-and-antimicrobial-immunity-Impaired"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,9,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.154.3.821","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,9,1]]}}}