{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T01:25:17Z","timestamp":1773624317917,"version":"3.50.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,6,1]]},"abstract":"<jats:p>Experimental murine listeriosis was used as a model to investigate the immunological basis for the age-associated decline in antimicrobial immunity. The reduced capacity of protective T cells from Listeria-immune senescent mice to adoptively immunize normal syngeneic recipients could not be attributed to inhibition of their activity by suppressor cells. Radiolabeled enriched splenic T cells from Listeria-immune young or senescent donors exhibited an identical distribution pattern after an intravenous infusion into young recipients. Moreover, cells from Listeria-immune young donors showed markedly greater protective capacity than cells from senescent immune donors whether the cells were transferred to young or senescent recipients. Dose-response analysis of protective T cells revealed that in response to immunizing infection (a) senescent mice generated 10-fold fewer protective T cells, and (b) protective T cells from senescent mice were 100-fold less efficient than cells from young mice.<\/jats:p>","DOI":"10.1084\/jem.155.6.1870","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T21:00:50Z","timestamp":1088024450000},"page":"1870-1875","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Aging and antimicrobial immunity. Lowered efficiency of protective T cells as a contributing factor for the decreased resistance of senescent mice to listeriosis."],"prefix":"10.1084","volume":"155","author":[{"given":"P J","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1982,6,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/155\/6\/1870\/1662995\/1870.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/155\/6\/1870\/1662995\/1870.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:35:21Z","timestamp":1690245321000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/155\/6\/1870\/49181\/Aging-and-antimicrobial-immunity-Lowered"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1982,6,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.155.6.1870","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,6,1]]}}}