{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T22:17:22Z","timestamp":1697408242430},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,8,1]]},"abstract":"<jats:p>Lm-1 is an Igh-linked locus that codes for cell surface alloantigens (Lm-1 determinants) recognized by T lymphocytes. Using Lm-1 congenic strains and cold-target inhibition of anti-Lm-1-specific lysis by cytotoxic T lymphocytes, we were able to demonstrate differential expression of two distinct Lm-1 antigenic determinants. One determinant is expressed on the surface of T cell blasts, the other on a number of pre-B cell lines. Both determinants are present on B cell blasts. Macrophages also bear Lm-1 determinants, and possibly express a determinant not found on lymphocytes. Fibroblasts, (unstimulated) thymocytes, and immature T cells lack detectable Lm-1 determinants. These data indicate that expression of the Lm-1 locus is dependent on cell lineage and the stage of cell differentiation or activation. We propose that Lm-1 is a lymphocyte-macrophage differentiation locus containing a number of structurally and functionally related genes. Evidence was presented that Lm-1 may also serve as a histocompatibility locus of major importance for bone marrow transplantation. Specifically, when Lm-1-incompatible bone marrow cells and spleen cells (from normal or anti-Lm-1 immune mice) were transplanted into X-irradiated recipients, the maturation and\/or function of bone marrow-derived donor B cells was delayed or inhibited.<\/jats:p>","DOI":"10.1084\/jem.162.2.607","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T21:00:50Z","timestamp":1088024450000},"page":"607-624","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Expression of murine Lm-1 locus. Lm-1 determinants on lymphocytes and macrophages, and effects of Lm-1 incompatibility on bone marrow grafts."],"prefix":"10.1084","volume":"162","author":[{"given":"M M","family":"O'Toole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G C","family":"Bosma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Bosma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1985,8,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/162\/2\/607\/1665986\/607.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/162\/2\/607\/1665986\/607.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:56:09Z","timestamp":1690246569000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/162\/2\/607\/58843\/Expression-of-murine-Lm-1-locus-Lm-1-determinants"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,8,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.162.2.607","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,8,1]]}}}