{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:13:30Z","timestamp":1760188410079},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,12,1]]},"abstract":"<jats:p>Human cyclic neutropenia occurs in children and adults. Adult-onset cyclic neutropenia is an acquired disease characterized by increased numbers of large granular lymphocytes (LGL), in contrast to childhood-onset cyclic neutropenia in which LGL counts are normal. We investigated the clonality of lymphocytes in these two groups of patients by assessing the rearrangement status of the T cell receptor beta chain gene. Patients with adult-onset cyclic neutropenia showed clonal rearrangement of the T beta gene whereas the children did not. Since LGL are known to have multiple regulatory effects on normal hematopoiesis, the finding of a clonal proliferation of this lymphocyte population implicates these cells in the pathogenesis of cyclic neutropenia.<\/jats:p>","DOI":"10.1084\/jem.164.6.2089","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"2089-2094","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Adult-onset cyclic neutropenia is a benign neoplasm associated with clonal proliferation of large granular lymphocytes."],"prefix":"10.1084","volume":"164","author":[{"suffix":"Jr","given":"T P","family":"Loughran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"4th","given":"W P","family":"Hammond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1986,12,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/164\/6\/2089\/1667425\/2089.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/164\/6\/2089\/1667425\/2089.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:07:19Z","timestamp":1690247239000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/164\/6\/2089\/49366\/Adult-onset-cyclic-neutropenia-is-a-benign"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1986,12,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.164.6.2089","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,12,1]]}}}