{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:36:56Z","timestamp":1774676216287,"version":"3.50.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,10,1]]},"abstract":"<jats:p>The SL\/Ni strain of mice spontaneously develops a necrotizing polyarteritis (NPA) that is histologically quite similar to human polyarteritis nodosa. This NPA most frequently affected parametrial tissues and\/or ovaries of females and small arterioles of the major salivary glands. Electron microscopic studies of early arterial lesions revealed massive budding of C-type particles from arterial smooth muscle cells just before or at the onset of arteritis. In addition, binding of mouse IgG and C3 to the plasma membrane of virus-producing smooth muscle cells was shown by immunoelectron microscopy. Antibody-bound muscle cells showed disintegration of their plasma membrane, but degeneration and necrosis of muscle cells were not associated with dense infiltration of neutrophils. SL\/Ni mice had natural antibodies that bound specifically to a fibroblast cell line infected with an endogenous ecotropic murine leukemia virus (MuLV) recovered from a SL\/Ni mouse. Most of the natural antibodies were cytotoxic in the presence of murine complement. Western blot immunoassays revealed that among 14 SL\/Ni female mice tested, all of the 9 mice that were affected by arteritis had anti-gp70 antibodies, while the 3 anti-gp70- mice were not affected. The presence of anti-p30 or anti-p15 (anti-p12) antibodies, which were also detected in some SL\/Ni mice, did not correlate with the development of arteritis. These results strongly support the hypothesis that NPA in SL\/Ni mice is mediated by the lysis of arterial smooth muscle cells due to the deposition of cytotoxic natural antibodies directed to cell membrane-bound gp70 molecules of an endogenous ecotropic MuLV.<\/jats:p>","DOI":"10.1084\/jem.166.4.890","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"890-908","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Pathogenesis of arteritis of SL\/Ni mice. Possible lytic effect of anti-gp70 antibodies on vascular smooth muscle cells."],"prefix":"10.1084","volume":"166","author":[{"given":"M","family":"Miyazawa","sequence":"first","affiliation":[{"name":"Department of Pathology, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Nose","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kyogoku","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1987,10,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/166\/4\/890\/1667862\/890.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/166\/4\/890\/1667862\/890.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:11:34Z","timestamp":1690247494000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/166\/4\/890\/58898\/Pathogenesis-of-arteritis-of-SL-Ni-mice-Possible"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.166.4.890","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,10,1]]}}}