{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:50:00Z","timestamp":1770472200068,"version":"3.49.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,3,1]]},"abstract":"<jats:p>Administration of Sn-protoporphyrin to Gunn rats that are characterized by a genetically determined absence of UDP-glucuronyl transferase activity for bilirubin, 24-30 h after birth, prevented the marked increase in serum bilirubin concentration that occurs in these animals in the postnatal period. A second administration of Sn-protoporphyrin at day 6 maintained serum bilirubin levels in the neonates at the initial level for an additional 6 d. In contrast, in untreated Gunn neonates, serum bilirubin levels increased substantially as expected during the immediate 2-wk period after birth. Studies in adult Gunn rats demonstrated that Sn-protoporphyrin administration diminished biliary bilirubin output, decreased tissue heme oxygenase activity, and did not alter hepatic cytochrome P450 levels. These findings raise the possibility that Sn-protoporphyrin may prove clinically useful in maintaining low levels of serum bilirubin in congenitally jaundiced individuals, such as patients with the Crigler-Najjar syndrome.<\/jats:p>","DOI":"10.1084\/jem.167.3.1247","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1247-1252","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Sn-protoporphyrin blocks the increase in serum bilirubin levels that develops postnatally in homozygous Gunn rats."],"prefix":"10.1084","volume":"167","author":[{"given":"T R","family":"Sisson","sequence":"first","affiliation":[{"name":"Newark-Beth Israel Medical Center, University of Medicine and Dentistry, New Jersey Medical College, Newark 07112."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G S","family":"Drummond","sequence":"additional","affiliation":[{"name":"Newark-Beth Israel Medical Center, University of Medicine and Dentistry, New Jersey Medical College, Newark 07112."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Samonte","sequence":"additional","affiliation":[{"name":"Newark-Beth Israel Medical Center, University of Medicine and Dentistry, New Jersey Medical College, Newark 07112."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Calabio","sequence":"additional","affiliation":[{"name":"Newark-Beth Israel Medical Center, University of Medicine and Dentistry, New Jersey Medical College, Newark 07112."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kappas","sequence":"additional","affiliation":[{"name":"Newark-Beth Israel Medical Center, University of Medicine and Dentistry, New Jersey Medical College, Newark 07112."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1988,3,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/167\/3\/1247\/1668554\/1247.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/167\/3\/1247\/1668554\/1247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:18:56Z","timestamp":1690247936000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/167\/3\/1247\/24059\/Sn-protoporphyrin-blocks-the-increase-in-serum"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,3,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.167.3.1247","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,3,1]]}}}