{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:46:42Z","timestamp":1762458402394},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,6,1]]},"abstract":"<jats:p>A decrease in thrombocyte count was observed in (NZW x BXSB)F1 (W\/B F1) mice at the age of greater than 5 mo, whereas megakaryocyte counts were found to increase in such mice. FACS analyses revealed the presence of both platelet-associated antibodies (PAA) and circulating antiplatelet antibodies. There is a correlation between the presence of these antibodies and the degree of thrombocytopenia. The transplantation of normal bone marrow cells from BALB\/c nu\/nu mice to W\/B F1 mice was found to have preventative and curative effects on thrombocytopenia; the mice showed normal platelet counts and no evidence of circulating antiplatelet antibodies. These results indicate that thrombocytopenia in W\/B F1 mice is due to the presence of antibodies to platelets. We therefore think that W\/B F1 mice serve as a useful animal model of idiopathic thrombocytopenic purpura (ITP) not only for elucidating the mechanism of the development of antiplatelet antibodies, but also for characterizing autoantibodies to platelets.<\/jats:p>","DOI":"10.1084\/jem.167.6.2017","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"2017-2022","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":103,"title":["(NZW x BXSB)F1 mouse. A new animal model of idiopathic thrombocytopenic purpura."],"prefix":"10.1084","volume":"167","author":[{"given":"N","family":"Oyaizu","sequence":"first","affiliation":[{"name":"Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Yasumizu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Miyama-Inaba","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Miyawaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Mitsuoka","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Morii","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1988,6,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/167\/6\/2017\/1668712\/2017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/167\/6\/2017\/1668712\/2017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:20:06Z","timestamp":1690248006000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/167\/6\/2017\/49478\/NZW-x-BXSB-F1-mouse-A-new-animal-model-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1988,6,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.167.6.2017","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,6,1]]}}}