{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T20:08:15Z","timestamp":1698523695252},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,9,1]]},"abstract":"<jats:p>Mice with congenital severe combined immunodeficiency disease (SCID) failed to mount either a T cell-independent IgM or T cell-dependent IgG anti-vesicular stomatitis virus (VSV) Indiana (IND) response. They did not generate cytotoxic T cells against lymphocytic choriomeningitis virus (LCMV) or vaccinia virus, but exhibited NK cell-like activities. When SCID mice were given bone marrow from syngeneic BALB\/c (H-2d) nu\/nu mice, all immune responses were expressed at control levels. If SCID mice were reconstituted with allogeneic H-2b C57BL\/6 nu\/nu bone marrow, the following primary anti-viral immune responses were measured. T-independent IgM anti-VSV-IND were normal, but T-dependent IgG anti-VSV-IND responses were absent. Cytotoxic T cell responses to LCMV and vaccinia virus were within normal ranges, were donor cell mediated, and were specific exclusively for the recipient SCID H-2d type. Since antigen presentation by spleen cells was functional in these chimaeras, the presented results indicate that (a) thymic selection of T cell restriction is strict; and (b) the type of T help necessary for B cells depends upon H-2-restricted contact between T and B cells, whereas, such contact-dependent help is not mandatory for the induction of virus-specific cytotoxic T cells.<\/jats:p>","DOI":"10.1084\/jem.168.3.1187","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1187-1192","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Thymic selection of H-2-incompatible bone marrow cells in SCID mice. Differences in T help for induction of B cell IgG responses versus cytotoxic T cells."],"prefix":"10.1084","volume":"168","author":[{"given":"R M","family":"Zinkernagel","sequence":"first","affiliation":[{"name":"Institut of Pathology, University Hospital, Z\u00fcrich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"R\u00fcedi","sequence":"additional","affiliation":[{"name":"Institut of Pathology, University Hospital, Z\u00fcrich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Althage","sequence":"additional","affiliation":[{"name":"Institut of Pathology, University Hospital, Z\u00fcrich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Hengartner","sequence":"additional","affiliation":[{"name":"Institut of Pathology, University Hospital, Z\u00fcrich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Reimann","sequence":"additional","affiliation":[{"name":"Institut of Pathology, University Hospital, Z\u00fcrich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1988,9,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/168\/3\/1187\/1669129\/1187.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/168\/3\/1187\/1669129\/1187.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:24:31Z","timestamp":1690248271000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/168\/3\/1187\/24118\/Thymic-selection-of-H-2-incompatible-bone-marrow"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,9,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.168.3.1187","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9,1]]}}}