{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:52:33Z","timestamp":1770738753198,"version":"3.49.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,4,1]]},"abstract":"<jats:p>We have generated an mAb, RR3-15, that recognizes murine TCRs containing the V beta 11 domain. Using this antibody to stain peripheral T cells, we have demonstrated that V beta 11-bearing T cells are largely absent from strains of mice that express the class II MHC molecule, I-E. Studies with F1 mice demonstrate that this effect is dominant, consistent with tolerance. The clonal deletion of V beta 11-bearing T cells appears to occur intrathymically, as immature but not mature V beta 11+ T cells are present in the thymus of I-E-bearing mice. Examination of B6 x DBA\/2 recombinant inbred strains demonstrates that the expression of I-E molecules is necessary for the clonal deletion of V beta 11-bearing T cells, but that other non-MHC genes control the clonal deletion process, as well. Paradoxically, only a small fraction of V beta 11+ T cell hybridomas are I-E reactive.<\/jats:p>","DOI":"10.1084\/jem.169.4.1405","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1405-1419","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":221,"title":["The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells."],"prefix":"10.1084","volume":"169","author":[{"given":"J","family":"Bill","sequence":"first","affiliation":[{"name":"Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Kanagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D L","family":"Woodland","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1989,4,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/169\/4\/1405\/1669589\/1405.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/169\/4\/1405\/1669589\/1405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:29:41Z","timestamp":1690248581000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/169\/4\/1405\/49990\/The-MHC-molecule-I-E-is-necessary-but-not"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,4,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.169.4.1405","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4,1]]}}}