{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:56:56Z","timestamp":1762160216781},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,9,1]]},"abstract":"<jats:p>Since class I MHC glycoproteins may function by \"screening and selecting\" degraded proteins, we wished to determine whether very short peptides made within a cell were detected and bound by MHC, and presented for T cell perusal. We show that a 22 amino acid viral sequence containing a Db-restricted nonameric CTL epitope is sufficient to direct CTL recognition\/lysis of H2b target cells. The mechanism of epitope presentation is by the \"natural\" endogenous route, and appears to direct lysis as effectively as wild-type virus infection, in which the epitope is part of a 236 residue glycoprotein.<\/jats:p>","DOI":"10.1084\/jem.170.3.1033","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1033-1038","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes."],"prefix":"10.1084","volume":"170","author":[{"given":"J L","family":"Whitton","sequence":"first","affiliation":[{"name":"Research Institute of Scripps Clinic, La Jolla, California 92037."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M B","family":"Oldstone","sequence":"additional","affiliation":[{"name":"Research Institute of Scripps Clinic, La Jolla, California 92037."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1989,9,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/170\/3\/1033\/1670292\/1033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/170\/3\/1033\/1670292\/1033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:36:44Z","timestamp":1690249004000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/170\/3\/1033\/50064\/Class-I-MHC-can-present-an-endogenous-peptide-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,9,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.170.3.1033","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,9,1]]}}}