{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:04:10Z","timestamp":1791295450292,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,11,1]]},"abstract":"<jats:p>Cytokines secreted in response to invading micro-organisms are important mediators of detrimental hemodynamic and metabolic changes in the host. To test whether cachectin\/TNF plays a role in triggering release of other cytokines in the setting of infection, anesthetized baboons were passively immunized against systemic cachectin\/TNF before infusion of a LD100 dose of live Escherichia coli. Bacteremia led to significant increases in circulating levels of cachectin\/TNF, IL-1 beta, and IL-6. Although bacterial endotoxin\/lipopolysaccharide is a potent stimulus for the synthesis and release of IL-1 and IL-6 in vitro, specific neutralization of cachectin\/TNF in vivo with mAb pretreatment significantly attenuated both the IL-1 beta and the IL-6 responses despite fulminant overwhelming bacteremia. These data suggest that cachectin\/TNF is essential for the initiation or amplification of IL-1 and IL-6 release during lethal gram-negative septic shock syndrome.<\/jats:p>","DOI":"10.1084\/jem.170.5.1627","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1627-1633","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":495,"title":["Antibodies to cachectin\/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia."],"prefix":"10.1084","volume":"170","author":[{"given":"Y","family":"Fong","sequence":"first","affiliation":[{"name":"Department of Surgery, New York Hospital, Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K J","family":"Tracey","sequence":"additional","affiliation":[{"name":"Department of Surgery, New York Hospital, Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L L","family":"Moldawer","sequence":"additional","affiliation":[{"name":"Department of Surgery, New York Hospital, Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D G","family":"Hesse","sequence":"additional","affiliation":[{"name":"Department of Surgery, New York Hospital, Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K B","family":"Manogue","sequence":"additional","affiliation":[{"name":"Department of Surgery, New York Hospital, Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Kenney","sequence":"additional","affiliation":[{"name":"Department of Surgery, New York Hospital, Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A T","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, New York Hospital, Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G C","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Surgery, New York Hospital, Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A C","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Surgery, New York Hospital, Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S F","family":"Lowry","sequence":"additional","affiliation":[{"name":"Department of Surgery, New York Hospital, Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1989,11,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/170\/5\/1627\/1670146\/1627.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/170\/5\/1627\/1670146\/1627.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:35:41Z","timestamp":1690248941000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/170\/5\/1627\/49995\/Antibodies-to-cachectin-tumor-necrosis-factor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989,11,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.170.5.1627","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,11,1]]}}}