{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:34:28Z","timestamp":1776263668721,"version":"3.50.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,11,1]]},"abstract":"<jats:p>Treatment of transformed breast duct epithelial cells with IL-6 produces a unique cellular phenotype characterized by diminished proliferation and increased motility. Human ductal carcinoma cells (T-47D and ZR-75-1 lines) are typically epithelioid in shape and form compact colonies in culture. Time-lapse cinemicrography shows that some untreated cells can transiently become fusiform or stellate in shape and separate from each other within a colony, but they usually rejoin their neighbors. While IL-6 suppresses the proliferation of these carcinoma cells, the IL-6-treated cells generally become stellate or fusiform and show increased motility. These changes persist as long as the cells are exposed to IL-6. This results in the dispersal of cells within colonies. The effects on cell growth, shape, and motility are reversible upon removal of IL-6. IL-6-treated T-47D cells display diminished adherens-type cell junctions, as indicated by markedly decreased vinculin-containing adhesions and intercellular desmosomal attachments. The effects on ZR-75-1 cell shape, colony number, and DNA synthesis are dependent on IL-6 concentration in the range from 0.15 to 15 ng\/ml. Higher concentrations are required in T-47D cells for equivalent effects. Anti-IL-6 immune serum blocks IL-6 action. IL-6 represents a well-characterized molecule that regulates both the proliferation and junction-forming ability of breast ductal carcinoma cells.<\/jats:p>","DOI":"10.1084\/jem.170.5.1649","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1649-1669","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":123,"title":["Interleukin 6 decreases cell-cell association and increases motility of ductal breast carcinoma cells."],"prefix":"10.1084","volume":"170","author":[{"given":"I","family":"Tamm","sequence":"first","affiliation":[{"name":"Rockefeller University, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Cardinale","sequence":"additional","affiliation":[{"name":"Rockefeller University, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Krueger","sequence":"additional","affiliation":[{"name":"Rockefeller University, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Murphy","sequence":"additional","affiliation":[{"name":"Rockefeller University, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L T","family":"May","sequence":"additional","affiliation":[{"name":"Rockefeller University, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P B","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Rockefeller University, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1989,11,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/170\/5\/1649\/1670552\/1649.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/170\/5\/1649\/1670552\/1649.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:39:12Z","timestamp":1690249152000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/170\/5\/1649\/50012\/Interleukin-6-decreases-cell-cell-association-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989,11,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.170.5.1649","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,11,1]]}}}