{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:37:50Z","timestamp":1770719870368,"version":"3.49.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,4,1]]},"abstract":"<jats:p>Studies were made on the effects of in vivo administration of anti-CD4 mAb, anti-CD8 mAb, or a combination of both mAbs on multiplication of bacteria, the levels of serum transaminases, and mortality in mice infected with Listeria monocytogenes. Results showed that in sublethal infection, CD8+ cells enhanced the peak of bacterial multiplication and liver cell necrosis, and CD4+ cells suppressed CD8+ cell-mediated enhancement. Results also showed that either CD4+ or CD8+ cells were necessary for, and capable of, mediating clearance of the bacteria. CD8+ cells were more efficient than CD4+ cells, but for optimal clearance both were necessary. In lethal listeriosis, treatment of mice with anti-CD8 mAb or a combination of both anti-CD4 and anti-CD8 mAbs, but not anti-CD4 mAb only, protected mice from death by decreasing multiplication of bacteria in the liver and spleen after a peak of approximately 10(8) CFU, and lowering the elevated serum levels of transaminases. These findings indicated that CD8+ cells were responsible for causing irreversible systemic Listeria infection and severe liver necrosis. In lethal listeriosis, administration of rMuIFN-gamma markedly prolonged survival by decreasing multiplication of bacteria and promoting recovery from liver necrosis.<\/jats:p>","DOI":"10.1084\/jem.171.4.1141","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1141-1154","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":53,"title":["Roles of CD4+ and CD8+ cells, and the effect of administration of recombinant murine interferon gamma in listerial infection."],"prefix":"10.1084","volume":"171","author":[{"given":"T","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Mieno","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Udono","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Shiku","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1990,4,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/171\/4\/1141\/1670818\/1141.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/171\/4\/1141\/1670818\/1141.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:43:08Z","timestamp":1690249388000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/171\/4\/1141\/49923\/Roles-of-CD4-and-CD8-cells-and-the-effect-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,4,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.171.4.1141","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,4,1]]}}}