{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:00:29Z","timestamp":1770750029271,"version":"3.50.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,6,1]]},"abstract":"<jats:p>Experimentally induced murine graft-vs.-host disease may be characterized by hypergammaglobulinemia, autoantibody formation, and immune complex-mediated organ system damage that mimics SLE. These autoimmune phenomena are mediated by abnormal Th-B cell cooperation, across MHC disparities, in which donor-derived allospecific Th cells recognize and interact with MHC class II antigens on the surface of recipient B cells. Microbial toxins, termed superantigens, which bind to MHC class II molecules and activate selected T cells based on TCR variable gene usage, may induce a similar form of Th-B cell interaction. In the present study, we generated and characterized human Th cell lines reactive with the Mycoplasma arthritidis superantigen (MAM). The essential observation is that resting human B cells bind MAM and present it to superantigen-reactive autologous or allogeneic Th cells, resulting in both Th cell activation and a consequent polyclonal Ig response by the superantigen-bearing B cells.<\/jats:p>","DOI":"10.1084\/jem.171.6.2153","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"2153-2158","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Helper T cell-dependent human B cell differentiation mediated by a mycoplasmal superantigen bridge."],"prefix":"10.1084","volume":"171","author":[{"given":"J R","family":"Tumang","sequence":"first","affiliation":[{"name":"Department of Medicine, Hospital for Special Surgery, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D N","family":"Posnett","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hospital for Special Surgery, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B C","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hospital for Special Surgery, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M K","family":"Crow","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hospital for Special Surgery, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hospital for Special Surgery, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1990,6,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/171\/6\/2153\/1670870\/2153.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/171\/6\/2153\/1670870\/2153.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:43:49Z","timestamp":1690249429000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/171\/6\/2153\/50135\/Helper-T-cell-dependent-human-B-cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1990,6,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.171.6.2153","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,6,1]]}}}