{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:09:46Z","timestamp":1790968186604,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,9,1]]},"abstract":"<jats:p>Infection with Staphylococcus aureus and the production of toxic shock syndrome toxin-1 (TSST-1) have been implicated in the pathogenesis of toxic shock syndrome. Previous in vitro studies have demonstrated that TSST-1 is a powerful but selective stimulator of human T cells, and that the majority of activated cells express the TCR V beta 2 gene segment. We therefore studied patients with toxic shock syndrome using a modification of the PCR to determine if expansion of V beta 2+ T cells is a marker of the in vivo disease process. Five of eight patients studied demonstrated markedly elevated levels of circulating V beta 2+ T cells, whereas none showed significantly elevated levels of T cells expressing other V beta gene segments. The results suggest that toxin-mediated T cell activation, which involves a large fraction of the human T cell repertoire, may be critical in the pathogenesis of this disease.<\/jats:p>","DOI":"10.1084\/jem.172.3.981","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"981-984","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":283,"title":["Selective expansion of T cells expressing V beta 2 in toxic shock syndrome."],"prefix":"10.1084","volume":"172","author":[{"given":"Y","family":"Choi","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Denver."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Lafferty","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Denver."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Clements","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Denver."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J K","family":"Todd","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Denver."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E W","family":"Gelfand","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Denver."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kappler","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Denver."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Marrack","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Denver."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B L","family":"Kotzin","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Denver."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1990,9,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/172\/3\/981\/1671341\/981.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/172\/3\/981\/1671341\/981.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:48:09Z","timestamp":1690249689000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/172\/3\/981\/24524\/Selective-expansion-of-T-cells-expressing-V-beta-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,9,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.172.3.981","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9,1]]}}}