{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:11:16Z","timestamp":1790867476290,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,11,1]]},"abstract":"<jats:p>The production of Interleukin 6 (IL-6) was studied during experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA) infection. IL-6 is present in the serum of mice with ECM, the highest concentrations being observed in mice with full-blown neurological syndrome. High IL-6 levels were also observed, however, in the absence of pathology in nonlethal malaria infection. These data suggest that IL-6 is produced in large amounts during malaria infection, but does not play a major role in the pathogenesis of ECM. A modulation of IL-6 production in ECM was achieved by in vivo treatment with other anticytokine antibodies: antibodies to interferon (IFN-gamma) or to tumor necrosis factor (TNF) abolished the rise of IL-6, while anti-IL-3 and anti-granulocyte\/macrophage colony-stimulating factor antibodies only partially prevented this rise, suggesting that the two cytokines IFN-gamma and TNF are important intermediates in IL-6 production. Passive immunization against IL-6 did not prevent ECM, but significantly reduced serum IgG levels in malaria-infected mice. Thus, by its effects on B cells, IL-6 may be involved in hypergammaglobulinemia and immune-complex diseases, e.g., glomerulonephritis observed during malaria infection.<\/jats:p>","DOI":"10.1084\/jem.172.5.1505","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1505-1508","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":65,"title":["Interleukin 6 production in experimental cerebral malaria: modulation by anticytokine antibodies and possible role in hypergammaglobulinemia."],"prefix":"10.1084","volume":"172","author":[{"given":"G E","family":"Grau","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Frei","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P F","family":"Piguet","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Fontana","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Heremans","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Billiau","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Vassalli","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P H","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1990,11,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/172\/5\/1505\/1895618\/1505.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/172\/5\/1505\/1895618\/1505.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T15:05:01Z","timestamp":1690643101000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/172\/5\/1505\/24320\/Interleukin-6-production-in-experimental-cerebral"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,11,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.172.5.1505","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11,1]]}}}