{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:36:26Z","timestamp":1757543786359},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,11,1]]},"abstract":"<jats:p>Intradermal administration of recombinant interferon gamma (rIFN-gamma) to lepromatous leprosy patients has converted the local histology toward a tuberculoid pattern. However, such changes have been confined to the site of injection. In contrast, in the present study, marked, intradermal accumulation of CD3+, CD4+, CD8+, and CD1a+ T cells and Leu-M5+ mononuclear phagocytes was induced at a distance from the sites of administration, in a dose-dependent manner, by 10 daily intramuscular injections of 10-30 micrograms rIFN-gamma\/m2. Mononuclear cell infiltration began within 3 d of onset of rIFN-gamma therapy and persisted at least 8 wk. Intramuscular administration of rIFN-gamma to lepromatous patients receiving concurrent chemotherapy can safely induce widespread histologic features of an upgrading reaction.<\/jats:p>","DOI":"10.1084\/jem.172.5.1509","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1509-1512","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Widespread intradermal accumulation of mononuclear leukocytes in lepromatous leprosy patients treated systemically with recombinant interferon gamma."],"prefix":"10.1084","volume":"172","author":[{"given":"C","family":"Nathan","sequence":"first","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Squires","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Griffo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Levis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C K","family":"Job","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A R","family":"Nusrat","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sherwin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Rappoport","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1990,11,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/172\/5\/1509\/1895487\/1509.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/172\/5\/1509\/1895487\/1509.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T15:02:33Z","timestamp":1690642953000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/172\/5\/1509\/24298\/Widespread-intradermal-accumulation-of-mononuclear"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,11,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.172.5.1509","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11,1]]}}}