{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T07:18:53Z","timestamp":1698304733467},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,2,1]]},"abstract":"<jats:p>T cells respond in a V beta-restricted fashion to bacterial enterotoxins bound to major histocompatibility complex (MHC) class II molecules. The requirement for CD4 in MHC class II-restricted T cell responses is very well established. We have assessed the role of CD4 in the T cell response to the bacterial enterotoxins Staphylococcal enterotoxin A (SEA), SEB, and toxic shock syndrome toxin 1. Three CD4- murine T cell hybridomas were transfected with the human CD4 molecule and assayed for interleukin 2 production in the presence of accessory cells bearing human MHC class II molecules and of the appropriate enterotoxin. The results clearly indicate that CD4- cells responded even to suboptimal concentrations of enterotoxin(s) equally well as CD4+ cells. Furthermore, expression of CD4 did not result in the acquisition of previously undetectable reactivity to enterotoxins. These results suggest that unlike the case with antigen-specific responses, formation of a T cell receptor-CD3\/CD4 supramolecular complex is not always essential for T cell activation by bacterial enterotoxins.<\/jats:p>","DOI":"10.1084\/jem.173.2.367","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"367-371","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["The CD4 molecule is not always required for the T cell response to bacterial enterotoxins."],"prefix":"10.1084","volume":"173","author":[{"given":"R P","family":"S\u00e9kaly","sequence":"first","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Croteau","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bowman","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Scholl","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Burakoff","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Geha","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1991,2,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/173\/2\/367\/1671985\/367.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/173\/2\/367\/1671985\/367.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:54:42Z","timestamp":1690250082000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/173\/2\/367\/24475\/The-CD4-molecule-is-not-always-required-for-the-T"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,2,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.173.2.367","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,2,1]]}}}