{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:01:58Z","timestamp":1770717718101,"version":"3.49.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,7,1]]},"abstract":"<jats:p>T cell clones recognizing the sperm whale myoglobin (SpWMb) epitope 110-121 in association with H-2d major histocompatibility complex class II molecules display a very limited heterogeneity of T cell receptor (TCR) V beta usage in DBA\/2 mice. All clones previously tested used the same V beta 8.2 gene segment and very restricted junctional regions. To investigate the significance of this observation in vivo, we immunized DBA\/2 mice with the intact SpW Mb protein or peptide 110-121. Only the V beta 8+ T cells showed any significant response to the 110-121 epitope. The response to peptide 110-121 was then analyzed in mice which, either as a consequence of antibody depletion or through genetic deletion of TCR V beta genes, lacked V beta 8+ peripheral T cells. DBA\/2 mice depleted of V beta 8+ T cells by antibody treatment responded poorly to the 110-121 peptide, and only at high antigen concentrations. In contrast, DBA\/2V beta a mice (homozygous for a deletion of multiple V beta gene segments including the V beta 8 family) made a response at least as great as that made by DBA\/2 mice, even though the DBA\/2V beta a mice had a very restricted TCR V beta repertoire compared with DBA\/2 mice. Mechanisms which might determine differences in the 110-121 specific response of DBA\/2, DBA\/2V beta a and F23.1-treated DBA\/2 mice are discussed.<\/jats:p>","DOI":"10.1084\/jem.174.1.83","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"83-92","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["The T cell receptor repertoire influences V beta element usage in response to myoglobin."],"prefix":"10.1084","volume":"174","author":[{"given":"G","family":"Ruberti","sequence":"first","affiliation":[{"name":"Department of Medicine, Stanford University School of Medicine, California 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Gaur","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University School of Medicine, California 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C G","family":"Fathman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University School of Medicine, California 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Livingstone","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University School of Medicine, California 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1991,7,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/174\/1\/83\/1672260\/83.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/174\/1\/83\/1672260\/83.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:57:41Z","timestamp":1690250261000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/174\/1\/83\/57364\/The-T-cell-receptor-repertoire-influences-V-beta"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,7,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.174.1.83","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7,1]]}}}