{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:28:39Z","timestamp":1790166519015,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,9,1]]},"abstract":"<jats:p>18 cloned T cell lines reactive with Borrelia burgdorferi proteins, all CD3+4+8-TCR-alpha\/beta+ and restricted by HLA class II proteins, were isolated from four patients with chronic Lyme arthritis. Analysis of these T cell clones indicated that the T cell response to the Lyme disease spirochete is not oligoclonally restricted; yet all produced the same pattern of lymphokines, resembling that of murine type 1 T helper cells, after antigen-specific or nonspecific stimulation. Therefore, a subset of human CD4+ T cells, with a distinct profile of lymphokine secretion, is selectively activated by the pathogen inciting this chronic inflammatory disease.<\/jats:p>","DOI":"10.1084\/jem.174.3.593","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"593-601","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":207,"title":["Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis."],"prefix":"10.1084","volume":"174","author":[{"given":"H","family":"Yssel","sequence":"first","affiliation":[{"name":"Department of Inflammation Biology, Syntex Research, Palo Alto, California 94303."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Shanafelt","sequence":"additional","affiliation":[{"name":"Department of Inflammation Biology, Syntex Research, Palo Alto, California 94303."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Soderberg","sequence":"additional","affiliation":[{"name":"Department of Inflammation Biology, Syntex Research, Palo Alto, California 94303."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P V","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Inflammation Biology, Syntex Research, Palo Alto, California 94303."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Anzola","sequence":"additional","affiliation":[{"name":"Department of Inflammation Biology, Syntex Research, Palo Alto, California 94303."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Peltz","sequence":"additional","affiliation":[{"name":"Department of Inflammation Biology, Syntex Research, Palo Alto, California 94303."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1991,9,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/174\/3\/593\/1672212\/593.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/174\/3\/593\/1672212\/593.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:57:14Z","timestamp":1690250234000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/174\/3\/593\/24406\/Borrelia-burgdorferi-activates-a-T-helper-type-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,9,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.174.3.593","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,9,1]]}}}