{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:18:56Z","timestamp":1779261536767,"version":"3.51.4"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,10,1]]},"abstract":"<jats:p>The antigen receptor expressed by mature T cells has been described as a disulfide-linked alpha\/beta or gamma\/delta heterodimer noncovalently associated with CD3, a complex of transmembrane proteins that communicates signals from the T cell receptor (TCR) to the cell interior. Studies suggest that all component chains must assemble intracellularly before surface expression can be achieved. We described, however, a CD4+\/CD8+ transformed murine thymocyte, KKF, that expresses surface TCR-beta chains in the absence of gamma, delta, and alpha proteins; these beta chains are only weakly associated with CD3-epsilon and CD3-zeta. Furthermore, KKF responds differently to stimulation through TCR-beta and CD3-epsilon, a functional dissociation that has been ascribed to a CD4+\/CD8+ subpopulation of normal thymocytes. KKF's unique TCR structure may offer an explanation for the functional anomalies observed.<\/jats:p>","DOI":"10.1084\/jem.174.4.775","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"775-783","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["Surface expression of a T cell receptor beta (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins."],"prefix":"10.1084","volume":"174","author":[{"given":"J A","family":"Punt","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R T","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T H","family":"Finkel","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kathiresan","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K J","family":"Blank","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pennsylvania, Philadelphia 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1991,10,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/174\/4\/775\/1672858\/775.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/174\/4\/775\/1672858\/775.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T02:03:55Z","timestamp":1690250635000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/174\/4\/775\/24285\/Surface-expression-of-a-T-cell-receptor-beta-TCR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.174.4.775","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10,1]]}}}