{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:45:24Z","timestamp":1758404724960},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,7,1]]},"abstract":"<jats:p>High-grade malignant nonHodgkin's lymphomas--five lymphoblastic, three pleomorphic, and two immunoblastic--developed in 10\/25 cynomolgus monkeys (Macaca fascicularis) followed for up to 746 d after infection with simian immunodeficiency virus, strain SIVsm. These lymphomas were shown to be associated with an Epstein-Barr (EB)-like cynomolgus B-lymphotropic herpesvirus (CBLV) by electron microscopy, by Southern blot hybridization with probes against human EBV, and by the expression of antigens corresponding to EBV-associated nuclear antigens (EBNAs) involved in human B cells transformation. Southern blot demonstration of immunoglobulin gene rearrangements and homogeneous EBV episomes indicated that all the lymphomas were CBLV-associated monoclonal B cell proliferations. Our findings suggest that these tumors correspond to the EBV-associated malignant lymphomas in acquired immunodeficiency syndrome with respect to clinical, morphological, phenotypic, and genotypic characteristics. The particular susceptibility of SIVsm immunodeficient cynomolgus monkeys for CBLV-associated lymphomagenesis appears therefore a useful model for EBV-associated lymphomas in humans.<\/jats:p>","DOI":"10.1084\/jem.176.1.281","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"281-286","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["A monkey model for Epstein Barr virus-associated lymphomagenesis in human acquired immunodeficiency syndrome."],"prefix":"10.1084","volume":"176","author":[{"given":"H","family":"Feichtinger","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Innsbruck, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S L","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Innsbruck, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Kaaya","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Innsbruck, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Putkonen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Innsbruck, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Gr\u00fcnewald","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Innsbruck, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Weyrer","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Innsbruck, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"B\u00f6ttiger","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Innsbruck, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Ernberg","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Innsbruck, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Linde","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Innsbruck, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Biberfeld","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Innsbruck, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1992,7,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/1\/281\/1673506\/281.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/1\/281\/1673506\/281.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T04:45:56Z","timestamp":1690260356000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/176\/1\/281\/24883\/A-monkey-model-for-Epstein-Barr-virus-associated"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,7,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.176.1.281","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7,1]]}}}