{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:26:57Z","timestamp":1791109617729,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,10,1]]},"abstract":"<jats:p>The clinical complications associated with severe and cerebral malaria occur as a result of the intravascular mechanical obstruction of erythrocytes infected with the asexual stages of the parasite, Plasmodium falciparum. We now report that a primary P. falciparum-infected erythrocyte (parasitized red blood cell [PRBC]) isolate from a patient with severe complicated malaria binds to cytokine-induced human vascular endothelial cells, and that this adhesion is in part mediated by endothelial leukocyte adhesion molecule 1 (ELAM-1) and vascular cell adhesion molecule 1 (VCAM-1). PRBC binding to tumor necrosis factor alpha (TNF-alpha)-activated human vascular endothelial cells is partially inhibited by antibodies to ELAM-1 and ICAM-1 and the inhibitory effects of these antibodies is additive. PRBCs selected in vitro by sequential panning on purified adhesion molecules bind concurrently to recombinant soluble ELAM-1 and VCAM-1, and to two previously identified endothelial cell receptors for PRBCs, ICAM-1, and CD36. Post-mortem brain tissue from patients who died from cerebral malaria expressed multiple cell adhesion molecules including ELAM-1 and VCAM-1 on cerebral microvascular endothelium not expressed in brains of individuals who died from other causes. These results ascribe novel pathological functions for both ELAM-1 and VCAM-1 and may help delineate alternative adhesion pathways PRBCs use to modify malaria pathology.<\/jats:p>","DOI":"10.1084\/jem.176.4.1183","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1183-1189","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":262,"title":["Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1."],"prefix":"10.1084","volume":"176","author":[{"given":"C F","family":"Ockenhouse","sequence":"first","affiliation":[{"name":"Immunology Branch, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington DC 20307."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Tegoshi","sequence":"additional","affiliation":[{"name":"Immunology Branch, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington DC 20307."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Maeno","sequence":"additional","affiliation":[{"name":"Immunology Branch, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington DC 20307."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Immunology Branch, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington DC 20307."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ho","sequence":"additional","affiliation":[{"name":"Immunology Branch, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington DC 20307."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K E","family":"Kan","sequence":"additional","affiliation":[{"name":"Immunology Branch, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington DC 20307."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Thway","sequence":"additional","affiliation":[{"name":"Immunology Branch, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington DC 20307."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Win","sequence":"additional","affiliation":[{"name":"Immunology Branch, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington DC 20307."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Immunology Branch, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington DC 20307."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R R","family":"Lobb","sequence":"additional","affiliation":[{"name":"Immunology Branch, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington DC 20307."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1992,10,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/4\/1183\/1673799\/1183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/4\/1183\/1673799\/1183.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T04:48:14Z","timestamp":1690260494000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/176\/4\/1183\/24706\/Human-vascular-endothelial-cell-adhesion-receptors"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.176.4.1183","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10,1]]}}}