{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T15:20:30Z","timestamp":1765380030928},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,10,1]]},"abstract":"<jats:p>The effects of allogeneic bone marrow transplantation (BMT) on non-insulin-dependent diabetes mellitus (NIDDM) were examined using KK-Ay mice. KK-Ay mice reconstituted with KK-Ay bone marrow cells showed glycosuria, hyperinsulinemia, and hyperlipidemia. However, KK-Ay mice (H-2b) that had been lethally irradiated (9.0 Gy) and then reconstituted with T cell-depleted bone marrow cells from normal BALB\/c mice (H-2d) showed negative urine sugar with decreases in serum insulin and lipid levels 4 mo after BMT. Morphological recovery of islets and glomeruli was also noted after allogeneic BMT. These findings suggest that BMT can be used to treat not only a certain type of NIDDM but also its complications such as hyperlipidemia and diabetic nephropathy.<\/jats:p>","DOI":"10.1084\/jem.176.4.1233","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1233-1238","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Bone marrow transplantation as a strategy for treatment of non-insulin-dependent diabetes mellitus in KK-Ay mice."],"prefix":"10.1084","volume":"176","author":[{"given":"S","family":"Than","sequence":"first","affiliation":[{"name":"First Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Ishida","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Inaba","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Fukuba","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Seino","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Adachi","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Imura","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Ikehara","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Kansai Medical University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1992,10,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/4\/1233\/1673781\/1233.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/4\/1233\/1673781\/1233.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T04:48:17Z","timestamp":1690260497000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/176\/4\/1233\/24718\/Bone-marrow-transplantation-as-a-strategy-for"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.176.4.1233","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10,1]]}}}