{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:49:51Z","timestamp":1791229791888,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,10,1]]},"abstract":"<jats:p>A common feature of T cell acute lymphoblastic leukemias (T-ALLs) is the presence of structural alteration of the 5' part of the tal-1 locus, localized on chromosomal band 1p32. These alterations consist of either a t(1;14)(p32;q11) chromosomal translocation (3% of T-ALLs) or tald submicroscopic deletion (12-25% additional T-ALLs). We have characterized a case of T-ALL with t(1;14)(p32;q11) in which, unlike the majority of t(1;14), the recombination with the T cell receptor delta elements affected the 3' side of the tal-1 locus. In this case, tal-1 transcription is initiated from a promoter located within the fourth exon similarly to the DU 528 cell line. In a T-ALL bearing a t(1;14) affecting the 5' part of tal-1, two types of tal-1 transcripts were observed, namely those probably initiated from the D delta region juxtaposed to tal-1 by the translocation, and those from the exon 4 promoter. It is interesting that this exon 4 promotion was also found in leukemic T cell lines and T-ALL samples without apparent tal-1 genomic alteration. In contrast, no transcript initiated from the exon 4 promoter was found in T-ALL with tald1 or tald2 deletion. In these cells, tal-1 is expressed via SIL-tal-1 fused transcripts. Finally, this exon 4 initiation was detected neither in normal bone marrow, nor in malignant cells from the erythroid\/megakaryocytic lineages. Taken as a whole, these data suggest that the exon 4 promoter is specifically active in T cell lineage.<\/jats:p>","DOI":"10.1084\/jem.176.4.919","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"919-925","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["A third tal-1 promoter is specifically used in human T cell leukemias."],"prefix":"10.1084","volume":"176","author":[{"given":"O","family":"Bernard","sequence":"first","affiliation":[{"name":"U. 301 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM)-Institut de G\u00e9n\u00e9tique Mol\u00e9culaire (IGM), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Azogui","sequence":"additional","affiliation":[{"name":"U. 301 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM)-Institut de G\u00e9n\u00e9tique Mol\u00e9culaire (IGM), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Lecointe","sequence":"additional","affiliation":[{"name":"U. 301 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM)-Institut de G\u00e9n\u00e9tique Mol\u00e9culaire (IGM), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Mugneret","sequence":"additional","affiliation":[{"name":"U. 301 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM)-Institut de G\u00e9n\u00e9tique Mol\u00e9culaire (IGM), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Berger","sequence":"additional","affiliation":[{"name":"U. 301 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM)-Institut de G\u00e9n\u00e9tique Mol\u00e9culaire (IGM), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J","family":"Larsen","sequence":"additional","affiliation":[{"name":"U. 301 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM)-Institut de G\u00e9n\u00e9tique Mol\u00e9culaire (IGM), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Mathieu-Mahul","sequence":"additional","affiliation":[{"name":"U. 301 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM)-Institut de G\u00e9n\u00e9tique Mol\u00e9culaire (IGM), France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1992,10,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/4\/919\/1673621\/919.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/4\/919\/1673621\/919.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T04:46:59Z","timestamp":1690260419000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/176\/4\/919\/24721\/A-third-tal-1-promoter-is-specifically-used-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.176.4.919","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10,1]]}}}