{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:02:55Z","timestamp":1790751775293,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,11,1]]},"abstract":"<jats:p>Tumor necrosis factor alpha (TNF-alpha), a major mediator of inflammation, also possesses a wide pleiotropism of actions, suggesting its involvement in physiological conditions. TNF-alpha mRNA is present in mouse embryonic tissues and also in fetal thymus and spleen. Repeated injections of a monospecific polyclonal rabbit anti-mouse TNF-alpha antibody in mice, starting either during pregnancy or at birth, led to a severe but transient growth retardation, already present at birth, reaching a 35% decrease in body weight at 3 wk, with complete recovery at 8 wk. The insulin growth factor I (IGF-I) blood levels were decreased to about 50%; growth hormone release and other endocrine functions were unaltered. A marked atrophy of the thymus, spleen, and lymph nodes was also observed, with lymphopenia and impaired development of T and B cell peripheral lymphoid structures. The pathways involving TNF-alpha in IGF-I release and early body growth are probably distinct from those by which TNF-alpha participates in early development of lymphoid tissues, where its low physiological release may contribute to enhance lymphoid cell expansion.<\/jats:p>","DOI":"10.1084\/jem.176.5.1259","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1259-1264","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Tumor necrosis factor alpha is involved in mouse growth and lymphoid tissue development."],"prefix":"10.1084","volume":"176","author":[{"given":"S","family":"de Kossodo","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G E","family":"Grau","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Daneva","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Pointaire","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Fossati","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ody","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zapf","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P F","family":"Piguet","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R C","family":"Gaillard","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Vassalli","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1992,11,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/5\/1259\/1673500\/1259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/5\/1259\/1673500\/1259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T04:45:46Z","timestamp":1690260346000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/176\/5\/1259\/58250\/Tumor-necrosis-factor-alpha-is-involved-in-mouse"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,11,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.176.5.1259","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11,1]]}}}