{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:28:40Z","timestamp":1790944120815,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,12,1]]},"abstract":"<jats:p>Polymyositis mediated by gamma\/delta T cells is a unique disease in which autoaggressive T lymphocytes surround, invade, and destroy muscle fibers. Histochemically, the vast majority of muscle-infiltrating T cells in a patient with polymyositis were reactive with a pan-gamma\/delta T cell receptor (TCR)-specific monoclonal antibody (TCR-delta 1+), but unlike &amp;gt; 90% of peripheral blood gamma\/delta T cells, these lymphocytes did not react with V delta 1- or V gamma 9-specific antibodies (A13- and Ti gamma A-, respectively). Differential reactivity with two different V delta 2-specific monoclonal antibodies (BB3-\/TiV-delta 2+) indicated that the infiltrating T cells express a V delta 2-containing TCR with unusual additional structural features. Using conventional and anchored polymerase chain reaction for the analysis of TCR transcripts, we found a striking predominance of one unusual V delta 2-J delta 3 recombination and one V gamma 3-J gamma 1 recombination. Both the unusual phenotype (TCR-delta 1+\/A13-\/Ti gamma A-\/BB3-\/TiV-delta 2+) and the dominance of distinct TCR transcripts are compatible with the assumption that one T cell clone, which expresses a V gamma 3-J gamma 1-C gamma 2\/V delta 2-J delta 3-C delta disulfide-linked TCR, dominates among the infiltrating T cells of the polymyositis muscle specimen analyzed.<\/jats:p>","DOI":"10.1084\/jem.176.6.1785","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1785-1789","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Autoaggressive myocytotoxic T lymphocytes expressing an unusual gamma\/delta T cell receptor."],"prefix":"10.1084","volume":"176","author":[{"given":"G","family":"Pluschke","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Ciba-Geigy Ltd., Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"R\u00fcegg","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Ciba-Geigy Ltd., Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Hohlfeld","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Ciba-Geigy Ltd., Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A G","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Ciba-Geigy Ltd., Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1992,12,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/6\/1785\/1674032\/1785.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/6\/1785\/1674032\/1785.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T04:50:24Z","timestamp":1690260624000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/176\/6\/1785\/24755\/Autoaggressive-myocytotoxic-T-lymphocytes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,12,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.176.6.1785","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,12,1]]}}}