{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:02:08Z","timestamp":1770717728389,"version":"3.49.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,4,1]]},"abstract":"<jats:p>We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells. By itself it induced a modest degree of B cell proliferation, but together with anti-immunoglobulin (anti-Ig) antibody it greatly stimulated B cell proliferation, as determined by both [3H]thymidine uptake and increase in cell numbers. These data are evidence that the CD40 ligand on T cells provides a signal that drives B cell proliferation. This signal is synergistic with that delivered by anti-Ig antibody.<\/jats:p>","DOI":"10.1084\/jem.177.4.1209","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1209-1213","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":169,"title":["Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation."],"prefix":"10.1084","volume":"177","author":[{"given":"P","family":"Lane","sequence":"first","affiliation":[{"name":"Basel Institute for Immunology, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Brocker","sequence":"additional","affiliation":[{"name":"Basel Institute for Immunology, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hubele","sequence":"additional","affiliation":[{"name":"Basel Institute for Immunology, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Padovan","sequence":"additional","affiliation":[{"name":"Basel Institute for Immunology, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Lanzavecchia","sequence":"additional","affiliation":[{"name":"Basel Institute for Immunology, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"McConnell","sequence":"additional","affiliation":[{"name":"Basel Institute for Immunology, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1993,4,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/177\/4\/1209\/1674313\/1209.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/177\/4\/1209\/1674313\/1209.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T04:53:14Z","timestamp":1690260794000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/177\/4\/1209\/24901\/Soluble-CD40-ligand-can-replace-the-normal-T-cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.177.4.1209","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4,1]]}}}