{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:03:43Z","timestamp":1791349423627,"version":"4.3.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,4,1]]},"abstract":"<jats:p>To determine the fate of anti-DNA antibody-bearing B cells in normal mice, we generated transgenic mice bearing the heavy (H) and light (L) chain genes of a well-characterized anti-double-stranded DNA antibody. This antibody was originally isolated from a diseased MRL\/lpr mouse and has characteristics common to spontaneously arising anti-DNA antibodies. Results show that the H\/L transgene (tg) immunoglobulin receptor is not expressed by animals bearing both tgs, although single tg animals (H or L) express their transgenes. Young H\/L tg animals express few B cells, whereas adult H\/L tg animals maintain almost normal B cell numbers. Analysis of the immunoglobulin receptors used by adult B cells shows that all contain the tg H chain in association with endogenous L chains. These B cells transcribe the L tg as well as the rearranged endogenous L chain gene, and loss of endogenous L chain gene transcription results in resurrection of the 3H9 H\/L tg product. Examination of the endogenous L chains used by these cells shows that they represent a highly restricted subset of V genes. Taken together, these data suggest that autoreactive transgenic B cells can rearrange endogenous L chain genes to alter surface receptors. Those L chains that compete successfully with the L tg for H chain binding, and that create a nonautoreactive receptor, allow the B cell to escape deletion. We suggest that this receptor editing is a mechanism used by immature autoreactive B cells to escape tolerance.<\/jats:p>","DOI":"10.1084\/jem.177.4.999","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T03:56:10Z","timestamp":1088049370000},"page":"999-1008","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":676,"title":["Receptor editing: an approach by autoreactive B cells to escape tolerance."],"prefix":"10.1084","volume":"177","author":[{"given":"D","family":"Gay","sequence":"first","affiliation":[{"name":"Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Saunders","sequence":"additional","affiliation":[{"name":"Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Camper","sequence":"additional","affiliation":[{"name":"Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Weigert","sequence":"additional","affiliation":[{"name":"Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1993,4,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/177\/4\/999\/1674319\/999.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/177\/4\/999\/1674319\/999.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:53:26Z","timestamp":1690246406000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/177\/4\/999\/24916\/Receptor-editing-an-approach-by-autoreactive-B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.177.4.999","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4,1]]}}}