{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:59:32Z","timestamp":1770721172726,"version":"3.49.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,9,1]]},"abstract":"<jats:p>Peritoneal gamma\/delta T cells from Listeria-immune mice show an enhanced potential to expand when restimulated with antigens or mitogens in vitro (see companion paper [Skeen, M. J., and H. K. Ziegler. 1993. J. Exp. Med. 178:971]). When cocultured with peritoneal alpha\/beta T cells, the gamma\/delta T cell population expanded preferentially even when the in vitro stimulus was specific for the alpha\/beta T cell population. Purified gamma\/delta T cells did not respond to alpha\/beta T cell-specific stimuli. If isolated T cell subsets were recombined in cell mixing experiments, the resulting proliferative response was greater than additive. Irradiated alpha\/beta T cells could enhance the proliferation of responding gamma\/delta T cells, but the effect was unidirectional; i.e., irradiated gamma\/delta T cells did not stimulate responding gamma\/delta T cells. This effect appeared to be cytokine mediated and did not require cell-cell contact. Both recombinant interleukin 2 (rIL-2) and rIL-7 could support the expansion of the gamma\/delta T cells, while rIL-7 was only minimally stimulatory for the alpha\/beta T cells. The magnitude of the response by gamma\/delta T cells to rIL-7 exceeded the response to other in vitro stimuli, including immobilized anti-T cell receptor monoclonal antibody, and was 50-100-fold greater than the alpha\/beta T cell response to IL-7. This unique sensitivity of gamma\/delta T cells to IL-7 was strongly enhanced by the presence of accessory cells. These cells could be replaced by rIL-1, establishing a synergy for IL-1 and IL-7 as factors that could uniquely stimulate this gamma\/delta T cell population. Isolated peritoneal gamma\/delta T cells from Listeria-immune mice react to heat-killed Listeria preparations in the presence of macrophages accessory cells in a non-H-2-restricted manner. Considered collectively, these results suggest a potential mechanism by which gamma\/delta T cells can predominate in epithelial tissues and at sites of infection.<\/jats:p>","DOI":"10.1084\/jem.178.3.985","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"985-996","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Intercellular interactions and cytokine responsiveness of peritoneal alpha\/beta and gamma\/delta T cells from Listeria-infected mice: synergistic effects of interleukin 1 and 7 on gamma\/delta T cells."],"prefix":"10.1084","volume":"178","author":[{"given":"M J","family":"Skeen","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H K","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1993,9,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/178\/3\/985\/1675494\/985.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/178\/3\/985\/1675494\/985.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T05:50:22Z","timestamp":1690264222000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/178\/3\/985\/50816\/Intercellular-interactions-and-cytokine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,9,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.178.3.985","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9,1]]}}}