{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:24:46Z","timestamp":1791037486320,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,2,1]]},"abstract":"<jats:p>Interleukin 5 (IL-5) is the main factor that promotes the terminal differentiation of eosinophil progenitors (as indicated by colony formation assays), and enhances the effector capacity of mature eosinophils. IL-5 is produced by T lymphocytes, CD4-\/CD8- and mast cells and recently, messenger (m)RNA of this cytokine has been identified in eosinophils from patients with coeliac disease, asthma, or eosinophilic heart diseases. In this study, IL-5 mRNA and immunoreactive IL-5 protein were detected in tissue and blood eosinophils from patients with eosinophilic cystitis or hypereosinophilic syndromes but not in Crohn's disease. By electron microscopy associated to immunogold staining, immunoreactive IL-5 was identified in eosinophilic granules. After stimulation with IgA-, IgE-, or IgG-immune complexes, blood eosinophils were shown, by immunocytochemistry and by enzyme-linked immunosorbent assay, to secrete IL-5. These observations demonstrate that eosinophils, under physiological stimulation, can release significant amounts of IL-5, which may contribute to local eosinophil recruitment and activation.<\/jats:p>","DOI":"10.1084\/jem.179.2.703","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"703-708","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":222,"title":["Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion."],"prefix":"10.1084","volume":"179","author":[{"given":"S","family":"Dubucquoi","sequence":"first","affiliation":[{"name":"Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Desreumaux","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Janin","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Klein","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Goldman","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Tavernier","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Capron","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Capron","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1994,2,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/179\/2\/703\/1675848\/703.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/179\/2\/703\/1675848\/703.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T06:06:23Z","timestamp":1690265183000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/179\/2\/703\/57538\/Interleukin-5-synthesis-by-eosinophils-association"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,2,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.179.2.703","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2,1]]}}}