{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:49:41Z","timestamp":1784857781830,"version":"3.55.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1913,10,1]]},"abstract":"<jats:p>1. The serum of rabbits treated intravenously with neosalvarsan, and of syphilitic patients treated intravenously with salvarsan or neosalvarsan, has a definite spiroch\u00e6ticidal action upon Spiroch\u0153ta duttoni.<\/jats:p>\n               <jats:p>2. Although this spiroch\u00e6ticidal action is exerted in vitro, it can be demonstrated only after the treated spiroch\u00e6t\u00e6 are injected into susceptible animals.<\/jats:p>\n               <jats:p>3. A curative action of the serum of neosalvarsan-treated rabbits is exercised on mice infected with Spiroch\u0153ta duttoni.<\/jats:p>\n               <jats:p>4. The spiroch\u00e6ticidal action of the serum of salvarsan-treated rabbits and patients is markedly increased by heating at 56\u00b0 C. for thirty minutes.<\/jats:p>\n               <jats:p>5. The increased spiroch\u00e6ticidal action produced by heating is due in part to the destruction of some inhibitory substance contained in normal serum and in part to a direct effect of the heat upon the serum and salvarsan mixture.<\/jats:p>\n               <jats:p>6. Cerebrospinal fluid does not contain the inhibitory substance present in normal unheated serum.<\/jats:p>","DOI":"10.1084\/jem.18.4.435","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T22:31:16Z","timestamp":1087511476000},"page":"435-449","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["A STUDY OF THE SPIROCH\u00c6TICIDAL ACTION OF THE SERUM OF PATIENTS TREATED WITH SALVARSAN"],"prefix":"10.1084","volume":"18","author":[{"given":"Homer F.","family":"Swift","sequence":"first","affiliation":[{"name":"From the Hospital of The Rockefeller Institute for Medical Research, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W. M.","family":"Ellis","sequence":"additional","affiliation":[{"name":"From the Hospital of The Rockefeller Institute for Medical Research, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1913,10,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/18\/4\/435\/1121313\/435.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/18\/4\/435\/1121313\/435.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T06:37:20Z","timestamp":1601707040000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/18\/4\/435\/6937\/A-STUDY-OF-THE-SPIROCH%C3%86TICIDAL-ACTION-OF-THE-SERUM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1913,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1913,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.18.4.435","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1913,10,1]]}}}