{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:32:42Z","timestamp":1790015562128,"version":"4.0.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,7,1]]},"abstract":"<jats:p>The immunoglobulin E (IgE) response is generally considered an essential component of the host defense against parasitic helminths such as Schistosoma mansoni. In contrast, work on antischistosome vaccines suggests that interferon gamma (IFN-gamma) is the critical immune mediator for vaccine-induced immunity to the parasite. In this study, the total IgE response to a primary S. mansoni infection was suppressed by anti-IgE treatment in both normal mice and in mice with defective IFN genes (gene knockout [GKO]). Reduction of the IgE response resulted in decreased worm burden and a decrease in the number of eggs produced per worm in both normal and GKO mice. Whereas anti-IgE treatment also resulted in reduced hepatosplenomegaly, granulomas around existing schistosome eggs showed normal cellularity. Serum interleukin 4 levels fell in response to the reduction in serum IgE as well. The data suggest that IgE plays a detrimental, rather than beneficial, role for the host in schistosomiasis. Furthermore, the absence of IFN-gamma was found to be of little consequence to the host-response to adults or eggs in a primary schistosome infection.<\/jats:p>","DOI":"10.1084\/jem.180.1.43","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":78,"title":["Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice."],"prefix":"10.1084","volume":"180","author":[{"given":"P","family":"Amiri","sequence":"first","affiliation":[{"name":"Department of Immunology, Genentech, Inc., South San Francisco, California 94080-4990."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Haak-Frendscho","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genentech, Inc., South San Francisco, California 94080-4990."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Robbins","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genentech, Inc., South San Francisco, California 94080-4990."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"McKerrow","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genentech, Inc., South San Francisco, California 94080-4990."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genentech, Inc., South San Francisco, California 94080-4990."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Jardieu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genentech, Inc., South San Francisco, California 94080-4990."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1994,7,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/180\/1\/43\/1676049\/43.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/180\/1\/43\/1676049\/43.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T06:11:23Z","timestamp":1690265483000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/180\/1\/43\/58310\/Anti-immunoglobulin-E-treatment-decreases-worm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,7,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.180.1.43","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7,1]]}}}