{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:16:57Z","timestamp":1762100217963},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,12,1]]},"abstract":"<jats:p>Susceptibility to T lymphomas in mice is determined by a number of viral and host genetic factors. We analyzed the types and latent period of lymphomas spontaneously occurring in crosses between AKR\/Ms, a T lymphoma-prone mouse strain, and SL\/Kh, a pre-B lymphoma-prone strain. The incidence of T lymphomas in the F1 hybrids backcross to SL\/Kh as well as F2 generation mice indicated that a dominant host gene thymic lymphoma susceptible mouse-1 (Tlsm-1) of AKR\/Ms determined the type of lymphomas to be thymic. Linkage analysis with microsatellite markers assigned Tlsm-1 to the map position 61 cM from centromere of the chromosome 7. Close scrutiny of this region of AKXD recombinant inbred strains for spontaneous T lymphomas revealed the presence of Tlsm-1-like gene most likely between D7MIT71 (map position 62) and D7MIT13 (map position 70). On the other hand, a SL\/Kh-derived recessive allele at a major histocompatibility complex (MHC)-linked locus accelerated development of both T and B lymphomas.<\/jats:p>","DOI":"10.1084\/jem.180.6.2155","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"2155-2162","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["T lymphomagenesis is determined by a dominant host gene thymic lymphoma susceptible mouse-1 (TLSM-1) in mouse models."],"prefix":"10.1084","volume":"180","author":[{"given":"Y","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Shisa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Matsushiro","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kamoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kawarai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Hiai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1994,12,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/180\/6\/2155\/1676382\/2155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/180\/6\/2155\/1676382\/2155.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T06:29:08Z","timestamp":1690266548000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/180\/6\/2155\/25667\/T-lymphomagenesis-is-determined-by-a-dominant-host"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,12,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.180.6.2155","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12,1]]}}}