{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:55:43Z","timestamp":1791172543813,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,12,1]]},"abstract":"<jats:p>The receptor for macrophage colony stimulating factor (CSF-1), the c-fms gene product, is a key determinant in the differentiation of monocytic phagocytes. Dissection of the human and mouse c-fms proximal promoters revealed opposing roles for nuclear protooncogenes in the transcriptional regulation of this gene. On the one hand, c-ets-1, c-ets-2, and the macrophage-specific factor PU.1, but not the ets-factor PEA3, trans-activated the c-fms proximal promoter. On the other hand c-myb repressed proximal promoter activity in macrophages and blocked the action of c-ets-1 and c-ets-2. Basal c-fms promoter activity was almost undetectable in the M1 leukaemia line, which expressed high levels of c-myb, but was activated as cells differentiated in response to leukemia inhibitory factor and expressed c-fms mRNA. The repressor function of c-myb depended on the COOH-terminal domain of the protein. We propose that ets-factors are necessary for the tissue-restricted expression of c-fms and that c-myb acts to ensure correct temporal expression of c-fms during myeloid differentiation.<\/jats:p>","DOI":"10.1084\/jem.180.6.2309","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"2309-2319","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":99,"title":["Opposing actions of c-ets\/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes."],"prefix":"10.1084","volume":"180","author":[{"given":"M A","family":"Reddy","sequence":"first","affiliation":[{"name":"Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B S","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J","family":"Barnett","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I L","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Sweet","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Hume","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1994,12,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/180\/6\/2309\/1676645\/2309.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/180\/6\/2309\/1676645\/2309.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T06:36:06Z","timestamp":1690266966000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/180\/6\/2309\/25682\/Opposing-actions-of-c-ets-PU-1-and-c-myb"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,12,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.180.6.2309","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12,1]]}}}